Issue 013

BCRM Bulletin

This digital BCRM Bulletin gives an overview of recent developments in our center. Brain Center Rudolf Magnus represents all research and (international) educational activities of the UMC Utrecht Hersencentrum. Our mission is to perform high-level research in clinical and experimental neuroscience, whilst delivering an exceptional standard of care.
August 2018, 13th edition

Editorial

Prof. dr. Jeroen Pasterkamp, professor of Translational Neuroscience, has been appointed chairman of the UMC Utrecht Brain Center by the executive board of the UMC Utrecht. Pasterkamp has held the position ad interim since January 2017, after the departures of prof. dr. René Kahn and prof. dr. Marian Joëls. Within the BCRM, various facets, such as research, care, talent development and education come together. As chairman, Pasterkamp will be supported by a diverse and enthusiastic core team. Why did Pasterkamp decide to continue in this position and what are his ambitions and plans for the BCRM? You can see his explanation in the following video.

Jeroen Pasterkamp chairman Brain Center Rudolf Magnus

Jeroen Pasterkamp, Scientific director BCRM

The core team consists of the following people:

– Jeroen Pasterkamp – division Brain, department of Translational Neuroscience: chairman, research, social relevance

– Manon Benders – Division Women and Child, department of neonatology: vice-chairman, patient care, strategic programs

-Hilleke Hulshoff Pol – Division Brain, department of Psychiatry: facilities, including X-talks

– Jeroen Hendrikse – Division Imaging, department of Radiology: talent

– Robert Stokroos – Division of Surgical Specialties, department of ORL: patient care

– Leonard van den Berg – Division Brain, department of Neurology and Neurosurgery: valorization, clinical trials (U-TRIAL)

– Arjen Slooter – Division of Anasthesiology, Intensive Care and Emergency Medicine, department of Intensive Care: valorization, other than trials

– Mariken de Krom – Division Brain: education, internationalization, social relevance

– Joanne Karssenberg – Division Brain: communication, social relevance

ERC Starting Grants for Frank Meye and Maeike Zijlmans

In order to support gifted junior group leaders implementing their own research line, Brain Center Rudolf Magnus awards one to two Rudolf Magnus Young Talent Fellowships each year. This year the Fellowships went to Frank Meye and Jinte Middeldorp. The Fellowship provides the recipients with €150.000 to be spent on research as the recipient sees fit.

Stress eating – Frank Meye
When coping with stress, humans and animals alike tend to increase their intake of tasty comfort food. In today’s society such stress eating can quickly become problematic. Particularly in individuals prone to develop obesity or eating disorders characterized by binge eating, the ravenous intake of large amounts of food in a short period of time. Despite the important contribution of stress eating to these serious medical conditions, the neurobiology underlying this behavior remains unclear. The goal of this proposal is to understand (in a mouse model) both how stress causes specific neural circuit changes that drive consumption of comfort food, and to find ways to counteract this process. To this end, Frank Meye will use the latest approaches to unravel and manipulate neural network function, ranging from light-based control of neuron activity and electrophysiological recordings of neuronal communication.

Frank Meye

Brain surgery in epilepsy – Maeike Zijlmans
Epilepsy surgery is the only curative treatment option for epilepsy and can halt the negative effect of epilepsy on cognitive development in children. It is complex and not always successful and therefore nowadays only applied if medication fails. The goal of the project of Maeike Zijlmans is to recognize the core of epilepsy directly during surgery by using innovative recording and analysis methods of the high frequency electrical brain signal and to understand the effect on the healthy brain function. A simple method will lead to a higher success rate and thus more frequent usage and to a broader application, e.g. in people with brain tumours that would undergo otherwise unguided surgery to increase life expectancy, but often also suffer from seizures.

Maeike Zijlmans

U-TRIAL

UMC Utrecht wants to do more complex clinical trials in patients. In addition, these clinical trials must yield faster results than they currently do. Of course without sacrificing quality and patient safety. The engine behind this project will be the Utrecht Trial Innovation Alliance, in short U-TRIAL.

If new medicines or other treatments have been developed for patients, it is important to make sure that they are applicable as soon as possible. One of the ways to achieve this is to conduct clinical trials, experiments in which the effects of new findings in patients are determined. Such a trial is the last stage before innovations become available for large groups of patients, both in and outside UMC Utrecht. However, an analysis shows that the UMC Utrecht – certainly given its ambitions – does not carry out many leading clinical trials. Clinical trial generator within the Brain Center Rudolf Magnus is prof. dr. Leonard van den Berg. He has extensive experience in setting up and implementing clinical trials.

“U-TRIAL is succesful if we can contribute to identifying an effective therapy for our patients”

How many clinical trials have you set up to date and implemented?
I have set up eight investigator-initiated trials in ALS and inflammatory neuropathies, and was PI in over 20 pharma-initiated trials. Setting up a trial is always a huge undertaking, but it is important: we do so much research in our focus areas, generating good cellular or animal models of disease in the lab, genetics, imaging etcetera, but we must not forget the last step of translational research: good quality trials to discover an effective therapy for our patients .

Where do you think the biggest weakness of the UMC Utrecht in the field of clinical trials is?
I like to think in challenges, not weaknesses. The UMC Utrecht needs to be better recognized as a center that is able to set up and lead good clinical trials. Logistics and a good infrastructure are important. CRO’s and companies document the track record of centers in trials: how many patients are included in what timeframe, how long does it take to have a contract signed and a study approved by the ethical committee. The smoother the process towards starting a trial, the more attractive you are as a center. Another challenge is to have more PI’s in a leading role in international clinical trials. For that good patient cohorts and efficient disease-specific trial networks are important. Other aspects to make our center more successful could be: expertise in trial design and data management or setting up online and face-to-face training modules and certification process for outcome measures in clinical trials

Why is U-TRIAL important?
We should strive for excellence. This can only be achieved by a concerted effort.

How important is cooperation with other (academic) hospitals and for example the business community?

This is very important. As I said, networks of center, national and international, are very important for common and without any doubt for rare diseases. Another opportunity is that we have good access to an academic CRO, closely related to the UMC Utrecht, Julius Clinical in Zeist. Another aim of U-trial is to involve Julius Clinical in our trials where possible.

Where do you see opportunities and problems for research within the BCRM?
There are many opportunities and challenges. We could collaborate and share expertise better within BCRM in all aspects of clinical trials, data management, acquisition of trials, submission to ethical committee, etcetera. Another opportunity is the beginning of gene therapy and stem cell trials, exciting areas for diseases involving the nervous system. The anti-sense therapy and future gene therapies in SMA are a good example. A common research line in trial design and (technology assisted) outcome measures would also be great opportunity.

When is U-TRIAL a success for you?
U-TRIAL is successful if more patients in our focus areas have access to experimental therapy by attracting more clinical trials, if we are more frequently in the lead in setting up and execute trials (both pharma and investigator initiated trials) at the UMC Utrecht, if we can reduce the burden of executing trials for investigators and patients, but above all if we can contribute to identifying an effective therapy for our patients.

Leonard van den Berg

Blended Psychiatry – Floortje Scheepers

Thirty years of research into the causes of psychiatric illnesses has still yielded too little. If it is up to professor of Psychiatry Floortje Scheepers, we will do things differently within the mental healthcare. During her inauguration on March 21, she pleaded ‘blended psychiatry’ during her lecture: combining patient experiences, knowledge of professional care providers and knowledge from data.

Floortje Scheepers

Marjolijn Ketelaar won the Outreach Award 2017. The jury praised her for the fact that she gives patients a substantial role. “This is unique, very important and an inspirational example to others.” Marjolijn is the program leader of the research line for child rehabilitation at the Utrecht Center for Rehabilitation Medicine Utrecht at the UMC Utrecht Brain Center Rudolf Magnus.

She has been involving patients in her research for a long time and has been able to link her work as a researcher to the lives of the patient. She really sets the standard for all researchers in the Brain Center on how to involve patients in their research.

There are still many patients with severe mental illnesses who do not benefit enough from current psychiatric care. They are faced with long waiting lists and ever-changing diagnoses. “We give patients the same medicines as they did thirty years ago and we often can not help them find their way back to an inclusive society,” says Floortje Scheepers. “I plead for more innovative care and research focused on the complexity of real practice.”

Blended Psychiatry
With blended psychiatry you do more justice to complexity. “Blended psychiatry stands for a trinity: the individual, subjective experience of the patient, professional knowledge of the care providers and knowledge derived from hard data. You need the same amount of all three of them to provide good care for that one patient with mental health problems. That seems simple but it is not. Blended psychiatry is slogging with each other, taking small steps. It requires a culture of learning rather than knowing, of collective intelligence and modesty instead of individual excellence. Only together we can make this happen.”

Psynet
In current psychiatric chain care, the patient is referred from one healthcare provider to another. No one seems to feel responsible for the whole. Most suicides and calamities in psychiatry take place during the transition from one emergency service to another. Network care is an alternative to this chain care. Assistance from different life domains are linked to each other. A good example is PsyNet: an innovative digital tool that enables the communication and information exchange in the personal network of the patient in a secure manner. Scheepers: “The patient has a central role in this and can build up his own personal network with formal but also informal care providers such as brothers, sisters, fathers, mothers or a neighbor. By better listening to who and what the patient needs and then connecting this together, we make it clear that nobody stands alone and that we have to do it together.”

Big data
By linking, analyzing and interpreting dynamic care data with patients, professionals and researchers, the complexity of psychological vulnerability is better understood. This creates a continuous learning process. That there is more aggression at the children’s clinic between 12 am and 1 pm is visible because all aggression incidents have been registered for years. The computer doesn’t know that between 12 am and 1 pm it’s lunchtime at the children’s clinic. But the nursing does. All those children at the table apparently are asking for problems. Solutions such as taking the tables apart and having lunch in two groups will come naturally.

Public evening about BCRM

On May 22we organized a public evening to share with the general public and our sponsors the work we do. During the event we gave a glimpse into the world of care and research in the field of neuroscience. You can watch a short video compilation of the evening below.

The presented magazine is made in collaboration with the New Scientist. It can also be viewed online. (Text is in Dutch, English translations of some interviews will be published on our website later.)

Fellowship Clinical Research Talent for Eric van Diessen and Wouter van Rheenen

Six talented medical specialists in training have received a fellowship in Clinical Research Talent from UMC Utrecht. Two of them work at the BCRM: Eric van Diessen and Wouter van Rheenen. They receive a scholarship which allow them to continue their scientific research nex to their training as a medical specialist.

Better and faster diagnostics for epilepsy

Eric van Diessens research focuses on epilepsy in children. “Combining clinical work and research has always been my ambition. I am convinced that my experience as a doctor has a positive influence on my clinical research questions and vice versa.” This motivated him to perform a PhD in pediatric neurology after his medical studies (SUMMA). He investigated how the network organization of the brain can be used to improve diagnostics and therapy in children with epilepsy.

Van Diessen: “The core of the research is a network analysis, which reduces complex systems such as the brain to a collection of points and connections: a network. During my PhD I showed, with the help of neurophysiological measurements, that children with epilepsy have a less efficient brain organization. These insights offer new opportunities for better and faster diagnostics in epilepsy. The award of the fellowship clinical research talent enables me to further develop my current projects and research ambitions and is a stepping stone for my future work as a pediatrician and researcher.”

enetic similarities

Wouter van Rheenens PhD focused on the genetic risk factors of amyotrophic lateral sclerosis (ALS). He described some new genetic variants that increase the risk of ALS, but he also showed that the genetic risk profile of ALS is a combination of many genetic risk factors.

After his PhD, Van Rheenen did 6 months of research at the University of Queensland in the Program for Complex Trait Genomics. Here he worked on models to better describe the genetic similarities between different diseases. Van Rheenen: “It is becoming clear that diseases that are clinically similar also have genetic similarities. With new techniques and genetic models we can study these similarities and use them to better understand the causes of diseases. Back in Utrecht, I will continue to work on this project and concentrate on various neurodegenerative diseases (Alzheimer’s, Parkinson’s, ALS and other diseases). The key question is whether these diseases, like many psychiatric disorders, are part of a spectrum or whether they should really be regarded as separate syndromes. This will have consequences for the diagnostics and new treatment strategies of these diseases in the future. Thanks to the fellowship I can continue this work in combination with my clinical work as a neurologist in training.”

“I am convinced that my experience as a doctor has a positive influence on my clinical research questions and vice versa”

Associate Professors

Four researchers of the BCRM have been appointed as Associate Professor:Huib Versnel, Hilgo Bruining, Tanja Nijboer and René Mandl. Who are they, what is the main goal of their research and what do they expect from being an associate professor?

Huib Versnel

After graduating in experimental physics in Leiden in 1986, I started my research career in auditory neuroscience in the electrophysiology laboratory of the otorhinolaryngology department in Leiden. I was attracted to hearing because of my passion for music and the single neuron intrigued me immensely adding to my enthusiasm for auditory neuroscience. After adventures in auditory cortex in Maryland and in England, and in the auditory midbrain in Nijmegen, I obtained a full research position, assistant professor, at the otorhinolaryngology department in Utrecht. Apart from running and supervising electrophysiological and histological studies in the lab on the themes of deafness and cochlear implantation, I started being involved in studies in patients. Since last year I am head of the laboratories of the department with a stronger emphasis on translation to the clinic.

I have a coordinating role in the research of the department, connecting lab and clinic. The goal of my research is improvement of hearing in patients suffering sensorineural hearing loss, including deaf patients with a cochlear implant. We attempt to reach that goal by 1) treatment of the auditory nerve to improve the neural interface of the cochlear implant 2) investigating stem cell methods to regenerate cochlear hair cells 3) developing objective measures that can be applied in patients in order to improve diagnosis, prognosis and expectancy management, and training. Research in the laboratory is directed towards translation to the clinic. The motivation of my research is the notion that hearing is crucial for the social human being, who connects through communication and who enjoys music. I expect to inspire students and colleagues in the lab and in the clinic to joyfully excel in hearing research. I expect to strengthen collaborations within the UMC Utrecht and Utrecht University, and with partners outside, and I expect to expand the research efforts, starting soon with a new postdoc for our stem cell research.

Hilgo Bruining

I am originally trained as a pediatrician and since 2010 a children’s psychiatrist in the UMC Utrecht. I have pursued this combination of clinical specialty by focusing on the overlap between autism spectrum disorder and epilepsy. The main goal of my research is to bring EEG to (child) psychiatric practice. It is my firm belief that without more objective physiological measures, the long-lasting deadlock in treatment development and application in developmental disorders will not be resolved. To achieve this aim, I founded the Sensory Processing Program (Zorgprogramma Prikkelverwerking) a couple of years ago. In this program, we integrate care and research and we are pioneering the inclusion of individual resting-state EEG and ERP (sensory evoked EEG) profiles for clinical decision making. Through this constant learning-by-doing approach, we can develop and test hypotheses on physiological variability and treatment effects. One of the great joys of this program is the collaboration with physicists at the experimental neurophysiology department of the VU in Amsterdam through which we try to use information processing theory to explain individual patient problems.

I expect from being an associate professor to further mature as a group leader and acquire more skills in research management. One example is that we are structuring a spin-off company around a patented biomarker. I also intend to develop a package of teaching materials to position neurophysiology far more dominantly in the curriculum of medical students and psychiatry interns. It really is time to bring biological psychiatry to the next level and start implementing the wealth of neuroscientific advances that have been achieved in the last decades.

Tanja Nijboer

My background is in Neuropsychology. I’ve always been fascinated by brain-behaviour relations and especially what happens when the brain is damaged. First, I started my research in the Psychology labs where we can manipulate our stimuli to the tiniest detail. About 8 years ago, I also started working at the De Hoogstraat Rehabilitation, and later at the Rehabilitation Department at the UMC Utrecht. This was a great opportunity because I could set some first steps in translating some well-known paradigms from Psychology and Psychophysics into potential clinical tests. My current field of research is neuropsychology of (multi-sensory) perception and spatial attention, where cognitive neuroscience, neuropsychological assessment, and cognitive rehabilitation come together.

Together with my team I aim to make a difference in the fields of neuropsychology and cognitive rehabilitation. Too often, we cannot assess and thus explain, predict, and treat the cognitive complaints patients have during their activities of daily living. In part this is due to the current neuropsychological assessment, which is pen-and-paper based. If we want to understand cognitive complaints and treat cognitive impairment in daily situations, we need to measure cognition in more dynamic and complex settings and use more detailed outcome measures. To these aims, I work together with industry; together with Atoms2Bits I developed a Virtual Reality supermarket to measure cognitive skills in a near-real simulation. Also, we developed for example a digitised neuropsychological assessment together with Philips Research. It would be great if our tools and research can really make a difference in the field and lead to better understanding of the brain-behaviour relations when we combine our findings with the state-of-art imaging techniques, but also to better tailor-made treatments for the patients.

I already collaborate with many different people from different fields, for example industry, but also with researchers from the fields of AI, computer science, and cognitive neuroscience and physicians, clinical (neuro)psychologist and off course patients. I expect that this new position will broaden the opportunities to collaborate even further and expand my team.

René Mandl

I already work for over 20 years at the department of Psychiatry. After obtaining my masters degree in informatics (artificial intelligence) I first started to work as a scientific programmer which was followed by the opportunity to do a PhD given by Hilleke Hulshoff and René Kahn. I did my PhD on the development of diffusion-weighted MRI analysis techniques that could be used to study the role of the brains white matter in schizophrenia.

The main goal of my research is to better understand which parts of the brain are implicated in psychiatric diseases in order to improve patient treatment. The focus of my current research is on the layers of the brains cortical grey matter. This is done in close collaboration with Natalia Petridou from the 7 tesla MRI group and Bart Ferguson who works as a PhD student at the psychiatry department. We are looking for new ways to study the role of the individual cortical layers in psychiatric diseases. For example, we recently published a method to extract myeloarchitectural information from conventional 3 tesla MRI scans. This method was validated using the 7T scanner and allows us to look in a new way to the hundreds of MRI scans that are already available.

What I like about working as a technical person at the department of psychiatry is that it is a truly multidisciplinary environment. A part of my job is to act as an intermediair/translator between people with a medical background and people with a pure technical background. Another important aspect about my work that I really like is supervising (PhD) students. These bright young people come up with very interesting and original ideas.

I don’t think being an associate professor will change the nature of my work (which is a good thing because I like my work very much) but it will give me the possibility to apply for certain grants.

Joannes Juda Groen Senior prize for Nick Ramsey

Prof. dr. Nick Ramsey has won the Joannes Juda Groen Senior prize 2018. Ramsey is Professor of Cognitive Neuroscience and his research focuses on brain-computer interfaces. He combines basic brain research with, among other things, machine learning, technical sciences and medicine. A result has been that paralyzed patients (now two in the Netherlands) can control devices using brain activity and that virtual activity can be converted into actual movements.

Ramsey is very delighted with the prize. “It is an important recognition for the discipline-transcending and translational nature of our research, and endorses the importance of our work for the small but very function-limited target group, patients with the locked-in syndrome (LIS). The recognition is an important boost for the team and puts our research in the spotlight. It also gives us the opportunity to expand our research program and to reach more potential candidates. Ultimately, we also want to offer solutions to less severely paralyzed people to promote independence and participation in society.”

The prize will be awarded on the 20th of September during a public symposium entitled ‘Health is more than Medicine’. It is an initiative of SIGO: a Foundation for Interdisciplinary Behavioral Science Research.

Veni-grant dr. Danai Riga

The Dutch Organization for Scientific Research (NWO) has awarded 154 young scientists with a Veni-grant. Among these dr. Danai Riga working at the department of Translational Neuroscience of the BCRM in the group of dr. Frank Meye. She has gotten the grant for her proposal, ‘Keep calm and pay attention: a view from the inside’.

About her research

Stressful experiences are common in our everyday life. For example, taking an exam will inevitably stress us out. A ‘healthy’ amount of stress will help us choose between going out and studying for that exam. During the test, it will help us focus our attention and stay sharp, in order to answer the questions right. However, extreme stress will reduce our ability to pay attention to things that matter, and it will make us impulsive, taking decisions that we might later regret.

Riga: “My research will identify how stress is kept in check, to prevent inattention and impulsivity. For this, I will study in mice how stress changes the way brain regions communicate with each other during attention and decision-making. This Veni provides me with a unique opportunity to study the link between stress and psychiatric disorders, in a fantastic environment such as the BCRM at Utrecht University. My ultimate goal is to discover better treatments for stress-induced disorders. To this end, I look forward joining forces with Frank Meye and the rest of the Translational Neuroscience team!”

Danai Riga

Grants and Awards

UMC Utrecht Clinical Fellowship for Wouter van Rheenen and Eric van Diessen.

Gift from Vriendenloterij for research into the influence of stress in infants.

Grant from the ALS Foundation for Anita Beelen and Esther Kruitwagen.

MKB innovations grant for the spin-off companies of Bas Neggers (Brain Science Tools) and Nick Ramsey (BrainCarta).

Nick Ramsey has been awarded with the Joannes Juda Groen Senior award 2018.

Irene van der Schaaf
has been awarded with a PPS grant from the Heart Foundation.

Jan Veldink has received two grant, one form the EU (a JPND -“BRAIN-MEND”) and one from the ALS foundation (IGNAGE).

Jeroen Pasterkamp has received a grant from the ALS foundation (“ALS-on-a-chip”).

Elly Hol has received a grant from Alzheimer NL.

Marco Boks has been awarded a MKMB project (also participating are Elly Hol and Jeroen Pasterkamp).

Jeroen Slooter has received a H2020 grant for the development of the delirium monitor.

Caroline Junge, Carlijn van den Boomen and Chantal Kemner have together received a Marie Curie grant.

The research innovation group of Psychiatry has landed three grants/awards; the innovation award for PsyNet from the economic board rejoin Utrecht, a grant from ZonMW for Big Data and a Commit2Data grant for BigData compute visits data consortium.

Elly Hol has received a TOP grant from ZonMW together with Gabriel Rinkel and Mervyn Vergouwen.

Hilgo Bruining has received a grant from Vrienden van het WKZ

Marco Boks has been awarded with a grant from ZonMW.

Hilleke Hulshoff Pol has gotten a grant from NWO and the Brain Foundation.

Sara Durston and Inge Winter have gotten an AIMS-2 grant.

Valeria Bonapersona won a poster prize at the Dutch Neuroscience Meeting.

Rick Dijkhuizen has been awarded a NWO-TTW grant, together with colleagues from AMC and LU.

Vera Wielenga has obtained of the NWO graduate program master N&N grants.

Milou Straathof has received an ISMRM Exchange Program grant.

Danai Riga has gotten a NWO Veni-grant.

Publications

More than 30 top-10% papers were published by researchers from Brain Center Rudolf Magnus in the period January 2018 – May 2018.

Some highlights:


1. Westeneng HJ, et al., Bredenoord AL, van Es MA, et al., Veldink JH, van den Berg LH.Prognosis for patients with amyotrophic lateral sclerosis:development and validation of a personalised prediction model. Lancet Neurol.2018 May;17(5):423-433.

2. Hillen AEJ, Burbach JPH, Hol EM.Cell adhesion and matricellular support by astrocytes of the tripartite synapse. Prog Neurobiol. 2018 Feb 11. pii:S0301-0082(16)30047-8.

3. Verharen JPH, de Jong JW, Roelofs TJM, Huffels CFM, van Zessen R, Luijendijk MCM et al.A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states. Nat Commun. 2018 Feb 21;9(1):731.

4. Oviedo-Salcedo T, de Witte L, Kümpfel T, Kahn RS, Falkai P, Eichhorn P, Luykx J, Hasan A. Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders. Br J Psychiatry. 2018 May;212(5):318-320.

5. Sinke MRT, Otte WM, Christiaens D, Schmitt O, Leemans A, et al. Diffusion MRI-based cortical connectome reconstruction: dependency on tractography procedures and neuroanatomical characteristics. Brain Struct Funct. 2018 Feb 20.

6. van Maren-Suir I, Ketelaar M, Brouns B, van der Sanden K, Verhoef M. There is no place like @home!: The value of home consultations in paediatric rehabilitation Child Care Health Dev. 2018 May 7.

BCRM Theses

BCRM thesis #214
Mw. A. Reijnen (December 21, 2017) The relationship of school performance and mental health: Educational achievement as indicator of psychopathology

Dept. Psychiatry and dept. Translational Neuroscience

BCRM thesis #215
S. Mandija (January 23, 2018) Non-Invasive Characterization of Brain Tissue Electrical Properties with MRI

Division Imaging

BCRM thesis #216
Mw. M.L.T. Tataranno (January 25, 2018) Early biomarkers of brain development in preterm infants

Division Women & Baby

BCRM thesis #217
Mw. A.F. ten Brink (February 20, 2018) Visuospatial neglect after stroke: Heterogeneity, diagnosis and treatment

Dept. Rehabilitation, Physiotherapy and Sport

BCRM thesis #218
Mw. N.E.C. van Klink (February 22, 2018) High frequency oscillations in epilepsy: towards clinical application

Dept. Neurology & Neurosurgery

BCRM thesis #219
Mw. S. Koops (March 20, 2018) Discharging the voices: non-invasive brain stimulation as a treatment for hallucinations

Dept. Psychiatry

BCRM thesis #220
Mw. L. Kok (March 22, 2018) Psychopathology after cardiac surgery and intensive care treatment

Division Intensive Care and Dept. Psychiatry and dept. Translational Neuroscience

BCRM thesis #221
Mw. L.H. Scholtens (April 3, 2018) Brain connectivity from micro to macro scale

Dept. Psychiatry

BCRM thesis #222
Mw. L. Abramovic (April 3, 2018) The role of psychiatric medication in brain structure in bipolar disorder patients

Dept. Psychiatry

BCRM thesis #223
Mw.S.M. Peters (April 4, 2018) Social behavior in rats essential for translation research An ethological approach

Science Faculty, Dept. Pharmacology

BCRM thesis #224
E. van Tilborg (April 6, 2018) Towards improved treatment options for white matter injury in preterm infants

Division Women & Baby

BCRM thesis #225
Mw. M. Zwinkels (April 12, 2018) From exercise training to school-based sports; The effects on fitness and health in youth with physical disabilities

Dept. Rehabilitation, Physiotherapy and Sport

BCRM thesis #226
Mw. K. van Elst (April 19, 2018) Omega-3 polyunsaturated fatty acids in Autism Spectrum Disorders; of mice and men

Dept. Translational Neuroscience

BCRM thesis #227
Mw. F.E. Buma (May 3, 2018) Explaining Plasticity after stroke

Dept. Neurology & Neurosurgery and Dept. Rehabilitation, Physiotherapy and Sport

BCRM thesis #228
R. Mooiweer (May 15, 2018) Personalized 2D-selective RF excitation in high field MRI

Division Imaging

BCRM thesis #229
Mw. H.E. van Stralen (June 8, 2018) Stroke & body ownership

Division Imaging and Dept. Neurology & Neurosurgery

BCRM thesis #230
Mw. J.C. Outermans (June 14, 2018) Investigating and stimulating walking after stroke

Dept. Rehabilitation, Physiotherapy and Sport

BCRM thesis #231
Mw. G.G.J. Ramakers (June 21, 2018) Tinnitus and cochlear implantation: impact and outcomes

Division Surgical specialties

BCRM thesis #232
Mw. M. Prikken (June 22, 2018) In search of the self – On self-disturbances and social cognition in schizophrenia

Dept. Psychiatry

BCRM thesis #233
R. Kockelkoren (June 26, 2018) Imaging of Arterial Intracranial Calcification

Division Imaging

BCRM thesis #234
E.H.J. Voormolen (July 10, 2018) Computer-Assisted Surgery of the Skull Base: Contributions to Guidance and Imaging

Dept. Neurology & Neurosurgery

BCRM thesis #235
M.W. Alsem (July 10, 2018) Family needs and the role of information in paediatric rehabilitation care

Dept. Rehabilitation, Physiotherapy and Sport

Calendar

BCRM X-Talks 2018

The X-talks consist of a successful series of programs within the BCRM. The X-talks attract both students and senior researchers and provide a forum for inspiring discussion, knowledge transfer, and by bridging boundaries drives novel combined research efforts for the future. X-talks will always be held on a Friday between 3 and 5 pm in the David de Wied lecture hall (Stratenum, 4th floor).

X-Talk

Clinical Trials and Innovation

Location: David de Wied lecture hall

September 7, 2018

X-Talk

Genetic Risk Factors

Location: David de Wied Lecture hal

October 5, 2018

X-Talk

Environmental Risk Factors

Location: David de Wied Lecture hall

November 9, 2018

X-Talk

Translational Approaches

Location: David de Wied Lecture hall

December 7, 2018

X-Talk

BCRM Research Day

Location: Paushuize, Utrecht

November 16, 2018

Colophon

Editors: Mariken de Krom, Joanne Karssenberg, Vicki Kurapka
Mail: bcrm-secretariaat@umcutrecht.nl
www.umcutrecht.nl/bcrm

Design: Omtrent communicatie – Communicatie die ertoe doet